Local drug delivery to the ear has gained wide clinical acceptance, with the choice of drug
and application protocol in humans largely empirically-derived. Here, we review the
pharmacokinetics underlying local therapy of the ear using the drugs commonly used in
clinical practice as examples. Based on molecular properties and perilymph measurements
interpreted through computer simulations we now better understand the principles
underlying entry and distribution of these and other drugs in the ear. From our analysis, we …