[HTML][HTML] A potential role of interleukin 10 in COVID-19 pathogenesis

L Lu, H Zhang, DJ Dauphars, YW He - Trends in Immunology, 2021 - cell.com
L Lu, H Zhang, DJ Dauphars, YW He
Trends in Immunology, 2021cell.com
A unique feature of the cytokine storm in coronavirus disease 2019 (COVID-19) is the
dramatic elevation of interleukin 10 (IL-10). This was thought to be a negative feedback
mechanism to suppress inflammation. However, several lines of clinical evidence suggest
that dramatic early proinflammatory IL-10 elevation may play a pathological role in COVID-
19 severity.
A unique feature of the cytokine storm in coronavirus disease 2019 (COVID-19) is the dramatic elevation of interleukin 10 (IL-10). This was thought to be a negative feedback mechanism to suppress inflammation. However, several lines of clinical evidence suggest that dramatic early proinflammatory IL-10 elevation may play a pathological role in COVID-19 severity.
cell.com