The transcription factors aryl hydrocarbon receptor and MYC cooperate in the regulation of cellular metabolism
MC Lafita-Navarro, L Perez-Castro… - Journal of Biological …, 2020 - ASBMB
The transcription factor AHR (aryl hydrocarbon receptor) drives the expression of genes
involved in detoxification pathways in cells exposed to pollutants and other small molecules.
Moreover, AHR supports transcriptional programs that promote ribosome biogenesis and
protein synthesis in cells stimulated to proliferate by the oncoprotein MYC. Thus, AHR is
necessary for the proliferation of MYC-overexpressing cells. To define metabolic pathways
in which AHR cooperates with MYC in supporting cell growth, here we used LC–MS–based …
involved in detoxification pathways in cells exposed to pollutants and other small molecules.
Moreover, AHR supports transcriptional programs that promote ribosome biogenesis and
protein synthesis in cells stimulated to proliferate by the oncoprotein MYC. Thus, AHR is
necessary for the proliferation of MYC-overexpressing cells. To define metabolic pathways
in which AHR cooperates with MYC in supporting cell growth, here we used LC–MS–based …
