Primary sclerosing cholangitis (PSC) is a rare disorder characterised by multi-focal bile duct
strictures and progressive liver disease. Inflammatory bowel disease is usually present and
there is a high risk of cholangiocarcinoma and colorectal cancer. Most patients ultimately
require liver transplantation, after which disease recurrence may occur. With limited
therapeutic options and a lack of proven surveillance strategies, patients currently have
significant unmet needs. In the present seminar, we provide a comprehensive review of the …