[HTML][HTML] Fibroblast growth factor 21 (FGF21) inhibits chondrocyte function and growth hormone action directly at the growth plate
S Wu, A Levenson, A Kharitonenkov… - Journal of Biological …, 2012 - ASBMB
Background: Evidence suggests that fibroblast growth factor 21 (FGF21) inhibits longitudinal
bone growth. Results: FGF21 antagonizes the growth hormone (GH) stimulatory effects on
thymidine incorporation and collagen X expression in chondrocytes. Conclusion: FGF21
inhibits bone growth by antagonizing GH effects on chondrocyte proliferation and
differentiation. Significance: Increased FGF21 during food restriction may contribute to
growth failure by directly inhibiting chondrogenesis.
bone growth. Results: FGF21 antagonizes the growth hormone (GH) stimulatory effects on
thymidine incorporation and collagen X expression in chondrocytes. Conclusion: FGF21
inhibits bone growth by antagonizing GH effects on chondrocyte proliferation and
differentiation. Significance: Increased FGF21 during food restriction may contribute to
growth failure by directly inhibiting chondrogenesis.
