Vascular anomalies are localized defects of vascular development. Most of them occur
sporadically (ie, there is no familial history of lesions, yet in a few cases clear inheritance is
observed). These inherited forms are often characterized by multifocal lesions that are
mainly small in size and increase in number with patients' age. On the basis of these
inherited forms, molecular genetic studies have unraveled a number of inherited mutations
giving direct insight into the pathophysiological cause and the molecular pathways that are …