Differential expression of CXCR4 receptor in early and term human placenta

A Kumar, S Kumar, AK Dinda, K Luthra - Placenta, 2004 - Elsevier
Chemokines and their receptors play a crucial role in regulation of T-cell migration and
differentiation. Recent findings suggest that these proteins can also regulate cell functions
such as angiogenesis and proliferation. Besides, CXCR4, a chemokine receptor, is one of
the two major co-receptors for entry of the HIV virus during the late stages of HIV infection.
We have studied the expression of CXCR4 in early (8–10 weeks) and term human placenta.
Immunofluorescence staining and RT–PCR analysis revealed a differential expression of …