CXCR4, CXCR7, and CXCL12 are associated with trophoblastic cells apoptosis and linked to pathophysiology of severe preeclampsia
J Lu, WH Zhou, L Ren, YZ Zhang - Experimental and molecular pathology, 2016 - Elsevier
Preeclampsia is a pregnancy disorder with sudden onset of maternal hypertension and
proteinuria, which is characterized by defective cytotrophoblast invasion, increased
apoptosis in cytotrophoblast, and diminished syncytial differentiation. In this study, samples
from 11 mild preeclamptic patients, 18 severe preeclamptic patients, and 21 normal
pregnant women were collected. The expression level of CXCL12 and its two receptors
(CXCR4 and CXCR7) in these samples and their relationship with apoptosis were …
proteinuria, which is characterized by defective cytotrophoblast invasion, increased
apoptosis in cytotrophoblast, and diminished syncytial differentiation. In this study, samples
from 11 mild preeclamptic patients, 18 severe preeclamptic patients, and 21 normal
pregnant women were collected. The expression level of CXCL12 and its two receptors
(CXCR4 and CXCR7) in these samples and their relationship with apoptosis were …
