Hearing threshold elevation precedes hair-cell loss in prestin knockout mice
X Wu, J Gao, Y Guo, J Zuo - Molecular brain research, 2004 - Elsevier
Our previous characterization of prestin knockout (−/−) mice demonstrated that prestin is
required for the eletromotility of outer hair cells (OHCs) and for the cochlear amplifier.
Because hair-cell loss was observed in the basal 25% of cochleae in adult prestin−/− mice, it
remained unclear how hair-cell loss progressed, whether hearing thresholds were elevated,
and whether OHCs had normal ultra-structure in young prestin−/− mice. We report here that
in prestin−/− mice, no significant hair-cell loss occurred before postnatal day 28 (P28); …
required for the eletromotility of outer hair cells (OHCs) and for the cochlear amplifier.
Because hair-cell loss was observed in the basal 25% of cochleae in adult prestin−/− mice, it
remained unclear how hair-cell loss progressed, whether hearing thresholds were elevated,
and whether OHCs had normal ultra-structure in young prestin−/− mice. We report here that
in prestin−/− mice, no significant hair-cell loss occurred before postnatal day 28 (P28); …
