[HTML][HTML] Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genomes⃞
PA Watkins, D Maiguel, Z Jia, J Pevsner - Journal of lipid research, 2007 - ASBMB
Acyl-coenzyme A synthetases (ACSs) catalyze the fundamental, initial reaction in fatty acid
metabolism." Activation" of fatty acids by thioesterification to CoA allows their participation in
both anabolic and catabolic pathways. The availability of the sequenced human genome
has facilitated the investigation of the number of ACS genes present. Using two conserved
amino acid sequence motifs to probe human DNA databases, 26 ACS family genes/proteins
were identified. ACS activity in either humans or rodents was demonstrated previously for 20 …
metabolism." Activation" of fatty acids by thioesterification to CoA allows their participation in
both anabolic and catabolic pathways. The availability of the sequenced human genome
has facilitated the investigation of the number of ACS genes present. Using two conserved
amino acid sequence motifs to probe human DNA databases, 26 ACS family genes/proteins
were identified. ACS activity in either humans or rodents was demonstrated previously for 20 …