To design useful experimental models of epilepsy, it is necessary to clearly understand the
known clinical-pathologic features of the disease process. Studies of mesial temporal lobe
epilepsy (MTLE) patients have identified several distinctive clinical and pathophysiologic
characteristics and many of these can be analyzed in experimental models. For example,
patients with typical MTLE have medical histories that often contain an initial precipitating
injury (IPI), are likely to have hippocampal sclerosis in the surgical specimen, and have …