Measles virus interaction with host cells and impact on innate immunity
D Gerlier, H Valentin - Curr Top Microbiol Immunol, 2009 - Springer
D Gerlier, H Valentin
Curr Top Microbiol Immunol, 2009•SpringerBecause viruses are obligate parasites, numerous partnerships between measles virus and
cellular molecules can be expected. At the entry level, measles virus uses at least two
cellular receptors, CD150 and a yet to be identified epithelial receptor to which the virus H
protein binds. This dual receptor strategy illuminates the natural infection and inter-human
propagation of this lymphotropic virus. The attenuated vaccine strains use CD46 as an
additional receptor, which results in a tropism alteration. Surprisingly, the intracellular viral …
cellular molecules can be expected. At the entry level, measles virus uses at least two
cellular receptors, CD150 and a yet to be identified epithelial receptor to which the virus H
protein binds. This dual receptor strategy illuminates the natural infection and inter-human
propagation of this lymphotropic virus. The attenuated vaccine strains use CD46 as an
additional receptor, which results in a tropism alteration. Surprisingly, the intracellular viral …
Abstract
Because viruses are obligate parasites, numerous partnerships between measles virus and cellular molecules can be expected. At the entry level, measles virus uses at least two cellular receptors, CD150 and a yet to be identified epithelial receptor to which the virus H protein binds. This dual receptor strategy illuminates the natural infection and inter-human propagation of this lymphotropic virus. The attenuated vaccine strains use CD46 as an additional receptor, which results in a tropism alteration. Surprisingly, the intracellular viral and cellular
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