Seek and hide: the manipulating interplay of measles virus with the innate immune system
K Ayasoufi, CK Pfaller - Current Opinion in Virology, 2020 - Elsevier
Highlights•Measles virus modulates innate immune responses through multiple
mechanisms.•Skewing with DC functions may be central for immunosuppression and
immune-amnesia.•Viral double-stranded RNA activates interferon and stress
responses.•The viral C protein is a polymerase co-factor reducing double-stranded
RNA.•The cellular ADAR1 is proviral by editing immunostimulatory double-stranded
RNA.The innate immune system is the first line of defense against infections with pathogens …
mechanisms.•Skewing with DC functions may be central for immunosuppression and
immune-amnesia.•Viral double-stranded RNA activates interferon and stress
responses.•The viral C protein is a polymerase co-factor reducing double-stranded
RNA.•The cellular ADAR1 is proviral by editing immunostimulatory double-stranded
RNA.The innate immune system is the first line of defense against infections with pathogens …
