[HTML][HTML] Complement C3a and C3a receptor activation mediates podocyte injuries in the mechanism of primary membranous nephropathy
S Gao, Z Cui, M Zhao - Journal of the American Society of …, 2022 - journals.lww.com
Background The complement system is highly activated in primary membranous
nephropathy (MN). Identifying the complement components that damage podocytes has
important therapeutic implications. This study investigated the role of C3a and the C3a
receptor (C3aR) in the pathogenesis of MN. Methods C3aR expression in kidneys and
circulating levels of C3a of MN patients were examined. Human podocyte damage was
assessed after exposure to MN plasma+/− C3aR blockade (SB290157, JR14a). C3aR …
nephropathy (MN). Identifying the complement components that damage podocytes has
important therapeutic implications. This study investigated the role of C3a and the C3a
receptor (C3aR) in the pathogenesis of MN. Methods C3aR expression in kidneys and
circulating levels of C3a of MN patients were examined. Human podocyte damage was
assessed after exposure to MN plasma+/− C3aR blockade (SB290157, JR14a). C3aR …
