[HTML][HTML] Filaggrin and beyond: new insights into the skin barrier in atopic dermatitis and allergic diseases, from genetics to therapeutic perspectives
N Stefanovic, AD Irvine - Annals of Allergy, Asthma & Immunology, 2023 - Elsevier
Atopic dermatitis is the most common inflammatory skin disease worldwide, affecting 20% of
children and 5% of adults. One critical component in the pathophysiology of atopic dermatitis
is the epidermal skin barrier, with its outermost layer-the stratum corneum (SC) being
conferring biochemical properties that enable resilience against environmental threats and
maintain homeostasis. The skin barrier may be conceptualized as a key facilitator of
complex interactions between genetics, host immunity, the cutaneous microbiome, and …
children and 5% of adults. One critical component in the pathophysiology of atopic dermatitis
is the epidermal skin barrier, with its outermost layer-the stratum corneum (SC) being
conferring biochemical properties that enable resilience against environmental threats and
maintain homeostasis. The skin barrier may be conceptualized as a key facilitator of
complex interactions between genetics, host immunity, the cutaneous microbiome, and …
